As the second-largest city in Spain, Barcelona has a seemingly endless amount of vacation rental options, so it helps to think about what you would like to experience most while you're there. For example, if you want beachfront accommodations and quick access to the vibrant nightlife that the city has to offer, then La Barceloneta is the place for you. Alternatively, if you prefer a more traditional and rich cultural experience, then the city's historic center, Barri Gotic, will better suit your needs. That said, the city of Barcelona is home to many different neighborhoods that are all worth considering, like El Raval and El Born, so be sure to do your research and make a decision based on your needs.